The Anti-Tumor Effect of Zinc on Renal Cell Carcinoma by Enhancing Autophagy

Renal cell carcinoma remains one of the most common malignant tumorsand is associated with significant challenges in drug therapy. Zinc has been reported to be pharmacological importance and immense potential inhibition renal cells. In order investigate inhibitory effect zinc on human line A498, its anti-proliferative activity was investigated using CCK8 assay. The oxidative stress status mitochondrial injury were detected by DCFH-DA JC-1 staining, respectively. expression autophagy-related proteins determined western blot analysis, which aimed at exploring antioxidant mechanisms zinc. Over 40% yield ROS more than four times number autophagosomes experimental group treated compared control group. Furthermore, led up-regulation Beclin 1-related signaling pathway late stage autophagy degradation. demonstrated a good A498 cells value IC50similar values natural products. One enhancing 1-dependent autophagy. Taken together, low cost properties, could become promising molecule satisfied anti-tumor treatment carcinoma.